Sunday, November 1, 2015

Decoding the Worm

Have you ever looked at a worm and think "Wow, I would love to know what makes that little thing work"? There's a very good chance that you have not, but scientists at the Research Institute of Molecular Pathology (IMP) in Vienna did just that and uncovered one of neuroscience's unknown questions.
This is the roundworm Caenorhabditis elegans. Manuel Zimmer and his team studied the brain activity of these worms and tracked how their isolated neurons work together as a group. By combining two different scientific technologies. The first on would be using "3D microscopy techniques to simultaneously and rapidly measure different regions of the brain" and the second would be "worms genetically engineered with a fluorescent protein that caused the worm’s neurons to flash when they were active." ("Vienna neuroscientists decode the brain activity of the worm," 2015) By observing the animals' reactions to trying to find food, Zimmer and his team "saw that most of the neurons are constantly active and coordinate with each other" acting as "an ensemble”, explains postdoctoral scientist Saul Kato. Since the C. elegans were debilitated the neurons' results reflected intentions instead of the physical act of finding food. ("Vienna neuroscientists decode the brain activity of the worm," 2015) Set up for freely moving worms, a different technique of microscopy enabled the scientists to identify the neurons that commence the worm's movement. It is found that there is "a direct correlation between the activity of certain networks and the impulse for movements." ("Vienna neuroscientists decode the brain activity of the worm," 2015) These activities represent short movements as well as their assembly into longer lasting behavioral strategies, like searching for food. The fact that these simple life forms' brains represent basic principles of brain function, even though the worm is only distantly related to mammals, could unlock some very important unanswered questions in the area of neurobiology("Vienna neuroscientists decode the brain activity of the worm," 2015)
Vienna neuroscientists decode the brain activity of the worm. (2015, October 15). Retrieved November 1, 2015.